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Beauty and Skin Care



Retention of water is one of the most important biological functions of HA in skin. (see details in Biological Functions and Health Benefits section)

HA content in human body decreases as we grow older

The highest HA content in normal human body is during the embryonic period. After birth, HA content decreases gradually as we grow older. If the relative HA content in the body of a 20-year-old human is designated as 100, it will decrease to 65, 45, and 25 respectively when the age is 30, 50, and 60 years old. The aging of skin, including wrinkles, dryness and roughness, is in close relation to the decrease of HA content in dermis (the deep part of skin).

Urula HA-DS works from the deep part of skin -- dermis

Oral administration of Urula HA-DS can recruit HA, DS, and CHS in the body. It can be digested and absorbed in digestive tract; under this condition, the long molecular chains of the mucopolysaccharides (HA, DS, and CHS) are cleavaged to very short pieces called oligosaccharides which can be absorbed into blood circulation and used as precursors to synthesize HA, DS and CHS in skin and other tissues. As a result, the content of these mucopolysaccharides in skin, surface (epidermis) and deep (dermis), are increased. The extracellular matrix (ECM) is impregnated and full of water, skin feels more elastic and looks more healthy and beautiful.

Urula HA-DS protects UV light from damaging the skin

HA, DS and CHS, effective scavengers of free radicals, also serve a protective role in epidermis by scavenging reactive oxygen species generated by ultraviolet radiation. The rapid turnover of HA will help to remove and clear noxious compounds from epidermis. DS can increase the density of skin cells, and prevent UV light from invading into skin.

For the inflamed skin by UV light, DS inhibits swelling and the formation of bled. Studies showed that UV light irradiation stimulates the biosynthesis of DS and HA in skin, and increases the contents of DS and HA in skin compensatively. Consequently, HA, DS, and CHS can inhibit the formation of fleck or sunspot induced by UV light in sun ray.

Urula HA-DS activates skin cells and enhances the functions of blood capillary

DS can activate the metabolism of skin cells, promote division and proliferation of basal cells, normalize the life circle of epidermis cells and expel fleck in its early period, inhibit keratinization of skin. As one of the important components of blood capillary, DS also can enhance the functions of blood capillary in skin, increase blood circulation, and prevent acidification of blood and the formation of fleck.
Comparison of wrinkled skin and healthy skin

(1) epidermis
(2) dermis
(3) HA
(4) collagen
(5) elastin
Wrinkled Skin
Mucopolysaccharides combined with collagen and elastin compose the extracellular matrix (ECM). When HA content decreases in dermis, skin wrinkles form.


Healthy Skin
While HA, DS and CHS content in dermis increase, the extracellular matrix (ECM) is impregnated and full of water; skin feels more elastic and looks healthy.
Case Studies

Click on the photos below to see the Case Studies of Urula HA-DS on beauty and skin care