Retention
of water is one of the most important biological functions
of HA in skin. (see details in Biological
Functions and Health Benefits section)
HA content in human
body decreases as we grow older
The highest HA content
in normal human body is during the embryonic period.
After birth, HA content decreases gradually as we
grow older. If the relative HA content in the body
of a 20-year-old human is designated as 100, it will
decrease to 65, 45, and 25 respectively when the age
is 30, 50, and 60 years old. The aging of skin, including
wrinkles, dryness and roughness, is in close relation
to the decrease of HA content in dermis (the deep
part of skin).
Urula HA-DS works from
the deep part of skin -- dermis
Oral administration of
Urula HA-DS can recruit HA, DS, and CHS in the body.
It can be digested and absorbed in digestive tract;
under this condition, the long molecular chains of
the mucopolysaccharides (HA, DS, and CHS) are cleavaged
to very short pieces called oligosaccharides which
can be absorbed into blood circulation and used as
precursors to synthesize HA, DS and CHS in skin and
other tissues. As a result, the content of these mucopolysaccharides
in skin, surface (epidermis) and deep (dermis), are
increased. The extracellular matrix (ECM) is impregnated
and full of water, skin feels more elastic and looks
more healthy and beautiful.
Urula HA-DS protects
UV light from damaging the skin
HA, DS and CHS, effective
scavengers of free radicals, also serve a protective
role in epidermis by scavenging reactive oxygen species
generated by ultraviolet radiation. The rapid turnover
of HA will help to remove and clear noxious compounds
from epidermis. DS can increase the density of skin
cells, and prevent UV light from invading into skin.
For the inflamed skin by UV light, DS inhibits swelling
and the formation of bled. Studies showed that UV
light irradiation stimulates the biosynthesis of DS
and HA in skin, and increases the contents of DS and
HA in skin compensatively. Consequently, HA, DS, and
CHS can inhibit the formation of fleck or sunspot
induced by UV light in sun ray.
Urula HA-DS activates
skin cells and enhances the functions of blood capillary
DS can activate the metabolism
of skin cells, promote division and proliferation
of basal cells, normalize the life circle of epidermis
cells and expel fleck in its early period, inhibit
keratinization of skin. As one of the important components
of blood capillary, DS also can enhance the functions
of blood capillary in skin, increase blood circulation,
and prevent acidification of blood and the formation
of fleck.
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Comparison
of wrinkled skin and healthy skin
(1) epidermis
(2) dermis
(3) HA
(4) collagen
(5) elastin
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Wrinkled Skin
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Mucopolysaccharides
combined with collagen and elastin compose
the extracellular matrix (ECM). When
HA content decreases in dermis, skin
wrinkles form. |
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Healthy Skin
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While HA, DS and
CHS content in dermis increase, the extracellular
matrix (ECM) is impregnated and full of
water; skin feels more elastic and looks
healthy. |
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Case Studies
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Click on the
photos below to see the Case
Studies of Urula HA-DS on beauty
and skin care
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